Discussion

Explanation:

The main sentence of the paragraph that decides the ending is “On this basis, Henry Perowne loses a number of cases each year.” Option 1 moves away from the core of the paragraph - losing patients.
Option 5 does not complete the paragraph and leaves one wanting for more data to explain the importance of hands being large.
Option 4 loses out on the sentence structure and style. There is no logical continuity to the paragraph.
Option 3 provides a logical finish to the paragraph by showing that inspite of the losing patients, Perowne is not concerned.
Option 2 brings in a disconnect to the idea from the paragraph. It states that other patients’ observations are also negative and those who stay with Perowne do so out of ignorance of available alternatives. This is not in continuation of the main idea expressed in the paragraph.
Hence, the correct answer is option 3.

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